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Claude Opus 4.5

Released 24 Nov 2025$5 input, $25 output per million tokensproprietaryAlso written as anthropic/claude-opus-4-5-20251101, Claude Opus 4.5 (Thinking), Claude Opus 4.5 (Nonthinking), anthropic/claude-opus-4-5-20251101-thinking, claude-opus-4-5-20251101, claude-opus-4-5-20251101-thinking

5 results on 3 of 13 boards, latest measured Sep 2026. Compare with other models

Clinical Benchmarks Index41.6Rank 26 of 1493 of 10 boardsAverage × multiplier 58.9 × 0.707 = 41.6This site’s own calculation. Working How it is computed

Results

Each line sits on its own board's scale. Tall tick: the board leader.

Clinical reasoning and knowledge

  1. MedXpertQA (MM)
    Qwen3.5 model card comparison; source-specific evaluation, not harmonized across vendors
    63.6
    Rank 16 of 22 here, 5 models on the boardLeader GPT-5.6 Sol 81.5
    Independent run
    Measured Feb 2026

Documentation and coding

  1. MedScribe (Vals AI)
    model ID anthropic/claude-opus-4-5-20251101-thinking; temperature=1; max_output_tokens=30000; compute_effort=high
    85.32
    Rank 26 of 105Leader Claude Opus 5.5 91.43
    Official leaderboard
    Measured Sep 2026
  2. MedScribe (Vals AI)
    model ID anthropic/claude-opus-4-5-20251101; temperature=1; max_output_tokens=30000; compute_effort=high
    83.25
    Rank 44 of 105Leader Claude Opus 5.5 91.43
    Official leaderboard
    Measured Sep 2026
  3. MedCode (Vals AI)
    model ID anthropic/claude-opus-4-5-20251101-thinking; compute_effort=high; temperature=1; max_output_tokens=30000
    49.16
    Rank 21 of 103Leader Claude Opus 5 63.57
    Official leaderboard
    Measured Sep 2026
  4. MedCode (Vals AI)
    model ID anthropic/claude-opus-4-5-20251101; compute_effort=high; temperature=1; max_output_tokens=30000
    45.17
    Rank 35 of 103Leader Claude Opus 5 63.57
    Official leaderboard
    Measured Sep 2026

Index working

The Clinical Benchmarks Index is this site's own calculation: a weighted average of the board scores times a multiplier for the boards behind it. How it is computed

  • MedScribe (Vals AI)85.3285.3×0.25, near its ceilingNear its ceiling: leader 91.4, weight 0.25model ID anthropic/claude-opus-4-5-20251101-thinking; temperature=1; max_output_tokens=30000; compute_effort=high
  • MedCode (Vals AI)49.1649.2×0.911model ID anthropic/claude-opus-4-5-20251101-thinking; compute_effort=high; temperature=1; max_output_tokens=30000
  • MedXpertQA (MM)63.663.6×0.463, near its ceilingNear its ceiling: leader 81.5, weight 0.463Qwen3.5 model card comparison; source-specific evaluation, not harmonized across vendors
Weighted average of 3 boards
58.9
Multiplier for 3 of 10 boards
× 0.707
Index
58.9 × 0.707 = 41.6

Score: the result on the board’s own 0 to 100 scale. Dot: this model; tick: the board’s leader. Weight: how much the board counts in the weighted average; bold where the board is near its ceiling and counts for less. Each result links to its quote and page; the line under it is the setting it was measured with.

Sources

The quote, page and document for each of the 5 results
  1. 26MedScribe (Vals AI) claude-opus-4-5-20251101-thinking 85.32
    Printed as 85.32%Official leaderboard, measured Sep 2026Configuration: model ID anthropic/claude-opus-4-5-20251101-thinking; temperature=1; max_output_tokens=30000; compute_effort=high
    Vals AI MedScribe leaderboard official leaderboard, Vals AI, 3 Sep 2026. Vals AI MedScribe leaderboard, View: All Models, Task: Overall, row 26 of 105 (Claude Opus 4.5 (Thinking)), Accuracy column; Updated 9/29/2026. Rendered BenchmarkView table; configuration from embedded astro-island BenchmarkView props, benchmarkView.default.tasks.overall["anthropic/claude-opus-4-5-20251101-thinking"].
    26 | Claude Opus 4.5 (Thinking) | 85.32%±1.90 | $5/$25 | 72.11s
    Every result from this document
  2. 44MedScribe (Vals AI) claude-opus-4-5-20251101 83.25
    Printed as 83.25%Official leaderboard, measured Sep 2026Configuration: model ID anthropic/claude-opus-4-5-20251101; temperature=1; max_output_tokens=30000; compute_effort=high
    Vals AI MedScribe leaderboard official leaderboard, Vals AI, 3 Sep 2026. Vals AI MedScribe leaderboard, View: All Models, Task: Overall, row 44 of 105 (Claude Opus 4.5 (Nonthinking)), Accuracy column; Updated 9/29/2026. Rendered BenchmarkView table; configuration from embedded astro-island BenchmarkView props, benchmarkView.default.tasks.overall["anthropic/claude-opus-4-5-20251101"].
    44 | Claude Opus 4.5 (Nonthinking) | 83.25%±1.93 | $5/$25 | 43.30s
    Every result from this document
  3. 21MedCode (Vals AI) claude-opus-4-5-20251101-thinking 49.16
    Printed as 49.16%Official leaderboard, measured Sep 2026Configuration: model ID anthropic/claude-opus-4-5-20251101-thinking; compute_effort=high; temperature=1; max_output_tokens=30000
    Vals AI MedCode leaderboard official leaderboard, Vals AI, 29 Sep 2026. MedCode leaderboard, Overall task, All Models expanded, rank 21 of 103; Accuracy column; board Updated 9/29/2026. Rendered table row; configuration from embedded BenchmarkView props benchmarkView.default.tasks.overall["anthropic/claude-opus-4-5-20251101-thinking"].
    21 | Claude Opus 4.5 (Thinking) | 49.16%±2.01 | $5/$25 | 60.84s
    Every result from this document
  4. 35MedCode (Vals AI) claude-opus-4-5-20251101 45.17
    Printed as 45.17%Official leaderboard, measured Sep 2026Configuration: model ID anthropic/claude-opus-4-5-20251101; compute_effort=high; temperature=1; max_output_tokens=30000
    Vals AI MedCode leaderboard official leaderboard, Vals AI, 29 Sep 2026. MedCode leaderboard, Overall task, All Models expanded, rank 35 of 103; Accuracy column; board Updated 9/29/2026. Rendered table row; configuration from embedded BenchmarkView props benchmarkView.default.tasks.overall["anthropic/claude-opus-4-5-20251101"].
    35 | Claude Opus 4.5 (Nonthinking) | 45.17%±1.89 | $5/$25 | 5.02s
    Every result from this document
  5. 16MedXpertQA (MM) Qwen3.5 model card… 63.6
    Printed as 63.6Independent run, measured Feb 2026Configuration: Qwen3.5 model card comparison; source-specific evaluation, not harmonized across vendors
    Qwen/Qwen3.5-397B-A17B model card model card, Alibaba / Qwen, 16 Feb 2026. Benchmark Results > Vision Language > Medical VQA; MedXpertQA-MM row, Claude 4.5 Opus column.
    | GPT5.2 | Claude 4.5 Opus | Gemini-3 Pro | Qwen3-VL-235B-A22B | K2.5-1T-A32B | Qwen3.5-397B-A17B MedXpertQA-MM | 73.3 | 63.6 | 76.0 | 47.6 | 65.3 | 70.0
    Every result from this document

Other Anthropic models: Claude 3.7 Sonnet, Claude Fable 5, Claude Fable 5.1, Claude Haiku 4.5, Claude Haiku 5.5, Claude Opus 4.1, Claude Opus 4.6, Claude Opus 4.7, Claude Opus 4.8, Claude Opus 5, Claude Opus 5.5, Claude Sonnet 4, Claude Sonnet 4.5, Claude Sonnet 4.6, Claude Sonnet 5, Claude Sonnet 5.5